Much less attention has been given to how this information will be used for the benefit of individuals with a serotonin-related susceptibility to depression, and little evidence exists concerning strategies to prevent depression in those with such a susceptibility.
1–5 In the future, genetic research will make it possible to predict with increasing accuracy who is susceptible to depression.
The research focus here has been on polymorphisms of the serotonin transporter, but other serotonin-related genes may also be involved. Research on the association between various polymorphisms and depression supports the idea that serotonin plays a role, not only in the treatment of depression but also in susceptibility to depression and suicide.
For the last 4 decades, the question of how to manipulate the serotonergic system with drugs has been an important area of research in biological psychiatry, and this research has led to advances in the treatment of depression.
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